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Gupta, Tarun; He, Xuehai; Uddin, Mostofa Rafid; Zeng, Xiangrui; Zhou, Andrew; Zhang, Jing; Freyberg, Zachary; Xu, Min (, Frontiers in Physiology)Macromolecular structure classification from cryo-electron tomography (cryo-ET) data is important for understanding macro-molecular dynamics. It has a wide range of applications and is essential in enhancing our knowledge of the sub-cellular environment. However, a major limitation has been insufficient labelled cryo-ET data. In this work, we use Contrastive Self-supervised Learning (CSSL) to improve the previous approaches for macromolecular structure classification from cryo-ET data with limited labels. We first pretrain an encoder with unlabelled data using CSSL and then fine-tune the pretrained weights on the downstream classification task. To this end, we design a cryo-ET domain-specific data-augmentation pipeline. The benefit of augmenting cryo-ET datasets is most prominent when the original dataset is limited in size. Overall, extensive experiments performed on real and simulated cryo-ET data in the semi-supervised learning setting demonstrate the effectiveness of our approach in macromolecular labeling and classification.more » « less
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Zhou, Meng; Li, Zechen; Tan, Bowen; Zeng, Guangtao; Yang, Wenmian; He, Xuehai; Ju, Zeqian; Chakravorty, Subrato; Chen, Shu; Yang, Xingyi; et al (, Proceedings of the 59th Annual Meeting of the Association for Computational Linguistics and the 11th International Joint Conference on Natural Language Processing (Volume 2: Short Papers))
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